This new platform integrates computational design and directed evolution to develop new antibodies, which are screened for their ability to bind to toxic aggregates that form in diseases like Parkinson's and Alzheimer's.
New antibody discovery platform can inform Alzheimer’s and Parkinson’s
In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that damage brain cells. The process of proteins spontaneously clumping is called protein aggregation and…